Methyl cinnamate (IFRA on TGSC vs. IFRA website)

[PeeWee678]

So when I look up Methyl cinnamate in TGSC it says this:

maximum skin levels for fine fragrances:
0.3100 % and are based on the assumption that the fragrance mixture is used at 20% in a consumer product (IFRA Use Level Survey). (IFRA, 2001)

Now for the confusing part: if I look it up on IFRA itself (https://ifrafragrance.org/safe-use/library), I get no results at all for CAS 103-26-4
So, is the information on TGSC erratic or out of date or what is it?

 

[jfrater]

Don't use TGSC for IFRA information. Methyl Cinnamate (103-26-4) is not restricted at all by any of the major standards (including IFRA up to IFRA 51).

 

[PeeWee678]

Don't use TGSC for IFRA information.

Thanks Jamie. In many cases the information on IFRA is correct on TGSC but I guess you're right in that the IFRA website is the one and only reliable source.

I use TGSC mainly because it's faster. On the IFRA site it's best practice to type in the CAS because the text search is very strict; not fuzzy at all and not finding it because of a typo happens easily. So first you have to copy the CAS (I do have those in my DB), paste it, open the document and find the values.

Well, it is what it is, unless I'm missing something...

 

[ourmess]

Well, it is what it is, unless I'm missing something...

Nope, you're not. Search the IFRA Standards themselves by CAS; that's about it. Treat anything you see anywhere else other than the IFRA library as merely a suggestion, and only take definitive answers directly from the source.

 

[pkiler]

IFRA is a CONSTANTLY moving Target. Bill Luebke at TGSC just gave up on trying to keep his website current with the stupidity of IFRA's moving target, and then just said, go see IFRA to get the scoop, if you want it.

 

[parker25mv]

methyl cinnamates (and other cinnamates) have near the same level of allergen potential as cinnamic alcohol.

isopropyl cinnamate NESIL 2900 micrograms/cm2
(source: https://fragrancematerialsafetyresource.elsevier.com/sites/default/files/7780-06-5.pdf )
benzyl cinnamate NESIL 4700 micrograms/cm2
(source: https://ifrafragrance.org/standards/IFRA_STD48_0162.pdf )

For comparison, one sources estimated the NESIL for benzyl alcohol at 5900 micrograms/cm2
(source: Benzyl alcohol / phenylmethanol MAK Value Documentation, A. Hartwig)

(the higher the NESIL value, the less irritation/allergen potential it has)

The cinnamates are only weak allergens and often in many studies no skin irritation was observed.
(source: A toxicologic and dermatologic assessment of related esters and alcohols of cinnamic acid and cinnamyl alcohol when used as fragrance ingredients, D. Belsito, Food and Chemical Toxicology 45, 2007 )

For additional comparisons with other cinnamic compounds, see one of my posts on page 2 in this thread:
Alright, I need help with this damn cinnamon note! (thread start date Jan 16, 2022)